ANA+/anti-dsDNA was related to low-quality embryos, low clinical pregnancy, and early miscarriage rate
The secondary endpoints were the British Isles Lupus Assessment Group index, serum complement activity (CH50) levels, anti-double-stranded DNA (dsDNA) antibody titer
Antibodies to dsDNA are specific to SLE and are pathogenic, both due to their ability to deposit in tissues through
HCQ is an anti-malarial and a disease-modifying anti-rheumatic drug (DMARD), which was observed to inhibit the replication of SARS-CoV-2 in vitro
0%, 30
Patients treated with the usual dose of HCQ had significantly decreased serum levels of anti-dsDNA antibodies at 3-month follow-up (mean change -3
Low Blood Concentration of Hydroxychloroquine Is a Marker for and Predictor of Disease Exacerbations in Patients With Systemic Lupus Erythematosus
Alt hough hydroxychloroquine (HCQ) has been reported to inhibit infection, evidence from Asian populations remains insufficient
Brazil’s president, Luiz Inácio Lula da Silva (known as Lula), aims to use his year at the helm of the G20 to convince the world of his most repeated promise, that
A new study published on the preprint server medRxiv * in June 2020 shows that the drug hydroxychloroquine (HCQ) suppresses a form of immunity called ‘trained immunity,’ with repercussions for ANA and anti-dsDNA can be seen in some patients with SCLE
[The absence of anti-dsDNA, however, does not exclude a diagnosis of Hydroxychloroquine, an antimalarial drug, can help bring down levels of pro-inflammatory molecules in systemic lupus erythematosus patients
Elevated anti-dsDNA, anti-Sm, or antiphospholipid antibodies: Elevated Anti-dsDNA antibody detection with CIA exhibited higher predictability for diagnosing LN than did ELISA
though individual circumstances may suggest use of aspirin or hydroxychloroquine and sometimes other medications if risk of blood clot sulfate (Plaquenil; Sanofi-Winthrop, Paris, France) prescribed at a stable dosage of 400 mg/day for at least 6 months
85 h (mean 0
) Anti-Ro/SSA and anti-La/SSB antibodies are present in approximately 30 and 20 percent of patients with SLE, respectively; however, both antibodies are more
Phase II trial includes 449 patients with SLE, it was found that there was a longer time to disease flare in (+) anti-dsDNA
Chloroquine (CQ) and hydroxychloroquine (HCQ) are “old” drugs but are still widely used in very diverse situations, including infectious diseases (1–3), rheumatic/inflammatory diseases (), or in clinical research protocols as add-on cancer therapy ()
Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated
A doctor may use the phrase "borderline lupus" when symptoms or blood test results suggest lupus, but there is not enough information for a definite diagnosis
However, even in this subset of patients with PLN, passive elevation of anti-dsDNA antibodies
Hydroxychloroquine also prevents SLE flares and improves lipid profile
stomach pain