See more Chlorpromazine is a medication used to manage and treat schizophrenia, bipolar disorder, and acute psychosis
Rapidly absorbed from GI tract and from parenteral sites of injection
Plasma concentrations and pharmacokinetic parameters determined by either analytical method showed wide intersubject variation, with the GLC-MS data showing relatively
) dose (10 mg) and three single oral
Plasma concentrations and pharmacokinetic parameters determined by either analytical method showed wide intersubject variation, with the GLC-MS data
Lung or breathing disease, like asthma
Thorazine (chlorpromazine) is a phenothiazine anti-psychotic medication used to treat psychotic disorders such as schizophrenia or manic-depression, and severe
Following the intravenous administration of a
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The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements
45 liter/kg and a k a
Ongoing monitoring is recommended for all patients taking antipsychotics
Each mL contains chlorpromazine hydrochloride 25 mg
Formulas relating these processes summarize the pharmacokinetic behavior of most drugs (see table Formulas Defining Jul 30, 2023 · Pharmacokinetics (PK) is the study of how the body interacts with administered substances for the entire duration of exposure (medications for the sake of this article)
The clinical benefits of clozapine prompted renewed efforts to develop novel antipsychotics
Rate The liver is the principal site of drug metabolism (for review, see [ 1])
Jul 7, 2020 · Lipophilicity has a dominant effect on many parameters that determine unbound drug exposure as well as drug potency
The elimination parameters for DOPAC and HVA were reestimated by the nonlinear least squares method
A mini literature review was conducted for PK parameters of 74 anticancer drugs, from the drug Oct 16, 2017 · The pharmacokinetic characteristics can be quantitatively expressed by its parameters, such as the elimination rate constant (denoted as K), half-life (t 1/2), apparent volume of distribution (V d) and total clearance rate (CL)
Mar 24, 2022 · To confirm the most appropriate PK/PD parameters and predict the values of PK/PD parameters for designing the dosage regimen, a mathematical model is needed
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It has been used in toxicology research and in examining/establishing regulatory guidelines as a nonrodent animal model
5 , and C 6 for doses 2, 3, and 4 are within the bioequivalence limits compared to the first dose but demonstrated a trend toward small increases with each additional dose
Clearance and volume of distribution were both seen to increase in these formulations (Guo et al
The elimination rate constant, k e, is the second pharmacokinetic parameter in this model, which governs the rate at which the drug concentration in the body declines over time
A total of 62 data for 24-h kinetics were analysed