Drug Monograph Black Box Warnings Adult Dosing Peds Dosing Contraindications/Cautions Drug Interactions Adverse Reactions Safety/Monitoring
It has a long-established efficacy for the prevention of
8,9,10 Nitrofurantoin is converted by bacterial nitroreductases to electrophilic
Considerations when
Nitrofurantoin is an antimicrobial agent obtained through the addition of a nitro group and a side chain containing hydantoin to a furan ring
006 Several classes of drugs, such as antibiotics, may interact with warfarin to cause an increase in warfarins anticoagulant activity and the clinical
We chose warfarin, tacrolimus, Para-aminohippurate, and Valsartan are MRP2 specific substrates, while Colchicine, Digoxin, and Nitrofurantoin are non-specific
generic drugs) are not considered
Find patient medical information for nitrofurantoin macrocrystal oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings
1
Vadlamudi RS, Smalligan RD, Ismail HM
Of the total drug interactions, 141 are major, 427 are moderate, and 70 are minor
Worry about maintaining an INR that is consistently within range
Warfarin (Coumadin, Jantoven) is a blood thinner used to treat and prevent blood clots
6 Warfarin has a narrow therapeutic index, requiring frequent laboratory monitoring to prevent life-threatening complications due to
Nitrofurantoin is an oral antibiotic widely used either short term to treat acute urinary tract infections or long term as chronic prophylaxis against recurrent infections
Drugs
20,21 Nitrofurantoin is of supratherapeutic INRs is particularly important as patients on dialysis have increased rates of bleeding with warfarin
Call your doctor for medical advice about side effects
Common nitrofurantoin side effects may include: headache, dizziness; gas, upset stomach; mild diarrhea; or
Common side effects may include: headache, dizziness, drowsiness, weakness; gas, indigestion, loss of appetite; nausea, vomiting; muscle or joint pain; rash, itching; or
Check INR q1-2 weeks and make serial adjustments per INR
Coli, Enterobacter cystitis, Enterococcus, Klebsiella, and Staphylococcus aureus
C) Avoid an excessive intake of citrus fruits
Results We identified 134 637 patients receiving Warfarin causes bleeding, as can Imatinib ; concurrent use might increase the risk of developing this effect
Manufacturer advises caution