Patients on Furosemide could be considered to be switched to Bumetanide whilst considering intravenous diuretics (Bumetanide 1mg is considered to be equivalent to
Oral Administration
Daily starting dose
07-0
The normal ceiling daily dose of furosemide above which little further natriuresis occurs is 80 mg once or twice daily, increasing to 160 and 240 mg in patients with chronic kidney disease (CKD) stages 3 and 4 or nephrotic syndrome or 80 Additional eligibility criteria were a history of chronic heart failure and receipt of an oral loop diuretic for at least 1 month before hospitalization, at a dose between 80 mg and 240 mg daily Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretics #Equivalent #Dose #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology
Side effects of Lasix and bumetanide that are similar include dehydration, nausea, and ringing in the ears
Bumetanide and Tоrsemide These loop diuretics are similar to Furosemide and are used for edema Diuretics Used In Heart Failure Oral Diuretics Recommended for Use in the Treatment of Chronic Heart Failure Drug Initial Daily Dose(s) Maximum Total Daily Dose Duration of action Loop Diuretics Bumetanide Oral: 0
Although the ratio of equipotent doses of furosemide to bumetanide is 40:1 in normal individuals, that ratio declines as kidney dysfunction progresses
Torsemide’s bioavailability tends to be >90% in patients with renal insufficiency, liver cirrhosis, and heart failure [11–15]
The major site of bumetanide action is the ascending limb of the loop
Specifically, it blocks the reabsorption of sodium and fluid from the kidney's tubules
Other Name: Lasix
In fact, Bumex is structurally related to Lasix but Bumex is about 40 times more potent on a milligram-to-milligram basis
Studies conducted in the 1970s showed that 50 mg of chlorthalidone once daily was equivalent to 50 mg of HCTZ twice daily