Lithium plus divalproex (N=110) was more effective than divalproex monotherapy (N=110) but not lithium monotherapy (N=110);
The authors compared the tolerability and efficacy of lithium carbonate and divalproex in 224 inpatients and outpatients age 60 or older with bipolar I disorder who
The proportions of patients improving at least 50% were higher for divalproex and lithium groups than for the placebo group: 48% for divalproex (P=
Suicide Risk in Bipolar Disorder During Treatment With Lithium and Divalproex | Bipolar and Related Disorders | JAMA | JAMA Network Distribution of Initial
An open-label trial of lithium monotherapy, divalproex monotherapy or their combination for bipolar I relapse prevention in 330 participants found that combination therapy with
The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium (Li) plus divalproex (DVPX) following relapse on either agent as
Among patients who did not stabilize on lithium and divalproex, the addition of lamotrigine was no more effective than placebo in reducing depression severity
ExxonMobil is making fast progress on the landmark lithium plan we announced just three months ago