Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot fully
Nature Reviews Chemistry - The unique properties of ferrocene-containing compounds make them useful for treating many diseases
Chemical structures of chloroquine (CQ), mefloquine (MQ), ferroquine (FQ), hydroxyl-ferroquine (FQ-OH) and ruthenoquine (RQ)
In addition, ferroquine retains all the features that have been identified as necessary in the structure of chloroquine (see Figure 4)
7-Chloroquinoline-based antimalarial drugs are effective in the inhibition of hemozoin formation in the food vacuole of the Plasmodium parasite, the causative agent of malaria
2003) following a similar procedure to that described for the ferroquine analog (Scheme
Section snippets Synthesis
Like SQ, FQ also forms complexes with
(K1) strains of Plasmodium falciparum, ruthenoquine analogues showed comparable
In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine
Chloroquine ferroquine and ruthenoquine structure
1 The 4-aminoquinoline chloroquine (CQ) (Figure (Figure1) 1) was used extensively after World War II for malaria prevention and treatment
55 From the original clone PyCQ S a clone PyCQ R was derived by 17 weeks of CQ
872; CAS Registry Number: 54-05-7; Chemical structure: This structure is also available as a 2d Mol file; Other names: 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-; Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl] The ferroquine and ruthenoquine were correlated to each other but not with CQ, confirming the lack of cross-resistance
Ferroquine (FQ or SR97193) is a novel antimalarial drug candidate, currently in development at Sanofi-Aventis
(B) Live imaging of LNCaP cells treated with vehicle, CQ (15 μM) or FQ (15 μM) for 24 h
Five compounds displaying an unprecedented binding mode of chloroquine to ferrocene through the bridging of the cyclopentadienyl rings were studied alongside their monosubstituted ferrocene analogues and organic fragments
Background Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline