Diltiazem and simvastatin interaction mhra

Indeed, diltiazem has been shown in pharmacokinetic studies to increase serum concentrations of both lovastatin and simvastatin (10,11), and isolated cases of myopathy have been reported in patients receiving simvastatin plus diltiazem (12,13). Simvastatin, a hydroxymethyl glutarate coenzyme A (HMG-CoA) reductase inhibitor Verapamil and diltiazem are known inhibitors of CYP3A4; the maximum dose of simvastatin is 20mg daily in patients taking these

2024-03-28
    Progesterone and water retention
  1. Authoring team
  2. Manufacturer advises use with caution or avoid
  3. Other calcium channel blockers do
  4. Interacting drug or food
  5. Other calcium channel blockers do not interact with simvastatin