If an ulcer occurs when platelets have Feb 1, 2016 · Omeprazole and other PPIs inhibit the CYP2C19 enzyme, which is a pathway for many medications
, clopidogrel, prasugrel, ticagrelor) are commonly prescribed for the prevention of recurrent cardiovascular events among patients with acute coronary syndromes (ACS) and/or those undergoing percutaneous coronary intervention (PCI)
Some PPI (proton pump inhibitors), like Prilosec, inhibit CYP2C19 and could cause Plavix to be less effective
They work by preventing specific blood cells (platelets) from clumping together
Proton pump inhibitors (PPIs) have been recommended for reducing the risk of gastrointestinal bleeding associated with dual antiplatelet therapy (aspirin plus clopidogrel)
Although only demonstrated in one subject, this seems to indicate There are 249 drugs known to interact with Plavix (clopidogrel), along with 3 disease interactions
They are the treatment of choice for several gastrointestinal disorders, such as peptic ulcer disease, esophagitis, gastroesophageal reflux disease, and H
1 The risk increases with the additional use of antiplatelet and antithrombotic Background: Published data indicated that combination use of clopidogrel and proton pump inhibitors (PPIs) may increase the incidence of major adverse cardiovascular events (MACEs)
1, 2 Low-dose aspirin has been associated with a 2-fold greater risk of major GI bleeding compared with placebo
However, using both together won't increase the risk of adverse effects
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Common interactions include pain among females, and chronic kidney disease among males
Long-term use may be associated with magnesium and vitamin B12 deficiency and an increased risk of bone fracture
Pantoprazole is approved by the Food and Drug Administration (FDA) to treat medical conditions such as gastroesophageal reflux disease (GERD), sometimes called acid reflux or heartburn
Plavix is sometimes taken together with aspirin
New data show that when clopidogrel and omeprazole are taken together, the effectiveness of Recent attention has been drawn to a potential drug-drug interaction observed between clopidogrel and proton pump inhibitors (PPIs)
2 percent of those taking only aspirin to 3
PPI therapy in combination with clopidogrel (Plavix) use may increase the risk of cardiac events
You started estrogen hormone replacement therapy or birth control
Moderate A search of the existing literature identified four case reports describing a possible interaction between methotrexate and PPIs
Please check with your md
Major: Highly clinically significant
I'd like to know in which order to take first, all together or hours apart
Ischemic Stroke
However, if you are currently well-managed on Lexapro and are having a good response to it, changing your dosage of it wouldn't generally be advised
Insulin is one of the oldest diabetes medications, and it's still used today
Plavix is in the drug class platelet aggregation inhibitors
It can also raise your risk of low blood glucose, low blood pressure, and bleeding if you take it with other medications that have these effects
Major: Highly clinically significant
An evaluation of the entire gastrointestinal tract did not reveal any possible causes of gastrointestinal blood loss
There was no significant difference in the risk of any event between the two groups
Summary The PPI-clopidogrel
Will atorvastatin and Plavix interact if I take them together? No, atorvastatin ( Lipitor ) and Plavix are not expected to interact
Subjects taking both drugs together showed a reduction in the clopidogrel-induced inhibition of platelet aggregation [3,4]
Additionally, while rare, PPIs may also cause drug interactions with other medications
Examples of proton pump inhibitors that can decrease the effectiveness of Plavix include: Published May 27, 2021 Last updated Feb 18, 2024 Key points Omeprazole can reduce the activity of Plavix, making it less effective and increase your risk of serious cardiovascular
We believe that the evidence indicates that, as stated in the clopidogrel label, concomitant use of clopidogrel and omeprazole should be avoided
However, the simultaneous intake of 10 mg of rabeprazole and clopidogrel did not alter the effect of clopidogrel on platelet function
Plavix is sometimes taken together with aspirin
However, based on how many medications you are prescribed, it can sometimes to difficult to reconcile dosing Key takeaways: Pantoprazole (Protonix) and omeprazole (Prilosec) are in a group of medications called proton pump inhibitors (PPIs)
Pantoprazole can interact with warfarin, HIV drugs, iron supplements, and more
PPI therapy in combination with clopidogrel (Plavix) use may increase the risk of cardiac events
Long-term use may be associated with magnesium and vitamin B12 deficiency and an increased risk of bone fracture
Clopidogrel is metabolized by cytochrome CYP450 2C19
They are the treatment of choice for several gastrointestinal disorders, such as peptic ulcer disease, esophagitis, gastroesophageal reflux disease, and H
Ticlopidine
FDA is alerting the public to new safety information concerning an interaction between clopidogrel ( Plavix ), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid
We investigated if pantoprazole, which has a different metabolism than omeprazole, diminishes the effectiveness of clopidogrel
A search of the existing literature identified four case reports describing a possible interaction between methotrexate and PPIs
Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan
Always consult your healthcare provider before starting or stopping any medication
2 percent of those taking only aspirin to 3
Avoid combinations; the risk of the interaction outweighs the benefit
The relevance of a particular drug interaction to a specific individual is difficult to determine
Prilosec changes the way the body processes certain antidepressants -- including citalopram (Celexa) and escitalopram (Lexapro) -- and certain medications that affect blood clotting -- including warfarin (Coumadin, Jantoven) and clopidogrel (Plavix) 1