Published on August 30, 2022 Key takeaways: There are many medications that interact with colchicine (Colcrys, Mitigare)
The purposes of this systematic review (SR) were to gather and appraise evidence surrounding the statin-colchicine drug interaction and discuss related risk-mitigation strategies
A drug-drug interaction (DDI) is a pharmacokinetic or pharmacological influence of 1 medication on another that differs from the known or anticipated effects of each agent alone
Colchicine is a substrate for the efflux transporter P-glycoprotein
Statins are primarily metabolized by the liver, albeit to varying degrees (Table 1)
Co-administration of certain drugs with statins may increase myotoxic effect, causing myopathy and varying degrees of rhabdomyolysis
Despite atorvastatin's proven safety, its use with certain drugs, such as colchicine, makes it a potential myotoxic drug
A study of statin-induced myopathy found that 40% of the patients received a drug that may have predisposed them to the muscle damage, and colchicine was the second-most-common interacting drug
The risk is greatest if you are elderly or have preexisting kidney disease
Used to take ibuprofen to tackle inflammation but since heart issues I've been told to avoid NSAIDS
Atorvastatin can help lower the risk of heart disease by lowering cholesterol and triglyceride (a type of fat) levels
Call your doctor for medical advice about side effects
Certain people are at greater risk for adverse effects and drug interactions, including older adults, people with renal impairment, and liver impairment
Many important interactions for simvastatin (Zocor) and atorvastatin relate to drugs that inhibit or induce metabolism via the cytochrome P450 (CYP3A4 Applies to: Colcrys (colchicine) and atorvastatin
Includes information on severity of interaction and the level of evidence for it
Stomach or bowel problems (eg, stomach ulcer)—May increase risk of stomach upset and can make these conditions worse
What key drug interactions are associated with atorvastatin, rosuvastatin, and simvastatin? The following drugs increase the risk of rhabdomyolysis when given with certain statins [BNF 76, 2018]: Amiodarone
Colchicine is an oral drug used to treat or prevent gout symptoms, or to treat familial Mediterranean fever
Those who think they are experiencing a drug interaction increased infections
Summary: Drug interactions are reported among 650 people who take Colchicine and Lipitor
Atorvastatin comes as a generic drug and as the brand-name drug Lipitor
Major: Highly clinically significant
The main types are: Drug-drug interaction
Medicines that interact with colchicine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with colchicine
Interaction Characteristics: CYP3A4 substrate; P-gp substrate; especially during initiation/titration; consider decr
Drug Interactions for Lipitor Drug Interactions That May Increase The Risk Of Myopathy And Rhabdomyolysis With LIPITOR
If concomitant use is decided, monitor patients for signs and Colchicine is useful for the prevention and treatment of gout and a variety of other disorders
Unless otherwise stated, interacting medications should be managed Applies to: Mitigare (colchicine) and atorvastatin
easy bruising, unusual bleeding, feeling weak or tired
Management of drug-drug interactions for patients receiving Paxlovid for 5 days Grapefruit juice can increase the blood levels of atorvastatin
Drug Interaction Studies
Atorvastatin and rosuvastatin may be resumed 3 days after completing Paxlovid®
Of the total drug interactions, 107 are major, 155 are moderate, and 5 are minor
Over 70% of patients developed ADEs on simvastatin or atorvastatin, and 80% of studies reported moderate-to-high intensity statins
A systematic review of the drug–drug interaction between statins and colchicine: Patient characteristics, etiologies, and clinical management strategies - Schwier - 2022 - Pharmacotherapy: The
Co-administration of certain drugs with statins may increase myotoxic effect, causing
Screening for autoimmune diseases and the determination of anti-HMG-CoA reductase antibodies were negative
Colchicine can also produce myopathy, and rhabdomyolysis has been reported in severe cases
Atorvastatin and colchicine interaction Maxspencer • 4 years ago • 14 Replies Had a really bad gout attack that started a couple of weeks ago and won’t
The risk is greatest if you are elderly or have preexisting kidney disease
Blood disorders (eg, aplastic anemia, granulocytopenia, leukopenia, pancytopenia, thrombocytopenia) or
AmLODIPine may increase the blood levels of atorvastatin
Of the total drug interactions, 44 are major, 294 are moderate, and 35 are minor
Sometimes, people take a supplement Colchicine: Avoid/use alternative: Risk of myopathy and rhabdomyolysis: Cyclosporine: Most atorvastatin drug interactions lead to increased amounts of atorvastatin in the body
Summary: Drug interactions are reported among 650 people who take Colchicine and Lipitor
The relevance of a particular drug interaction to a specific individual is difficult to determine
A number of studies and/or case reports have also reported a potential interaction between colchicine and certain statins, particularly atorvastatin and simvastatin, which are substrates for CYP3A4
Ritonavir
Azor
Atorvastatin is a P-glycoprotein substrate, and colchicine is a P-glycoprotein inhibitor; combining the two modifies the pharmacokinetics of the drug by increasing the bioavailability and organ Colchicine is useful for the prevention and treatment of gout and a variety of other disorders
Medicines that interact with colchicine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with colchicine
Consider the risk/benefit of concomitant use of colchicine with LIPITOR
Drug-drug interactions can be checked more completely at Liverpool COVID-19 Drug-Drug Interaction website
The man had a history of chronic renal insufficiency and diabetes mellitus
Consider consulting with a pharmacist for specific drug-drug interaction scenarios
colchicine dose during and x14 days after