Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease, especially in young children
Ribavirin (RBV) is a synthetic guanosine analog with a broad-spectrum of antiviral activity
Currently, ribavirin is 105 used mainly when the outcome of an RSV LRTI could be fatal, such as in
These include both indirect mechanisms (inosine monophosphate
Ribavirin therapy should only be considered for infections due to respiratory syncytial virus (RSV)
So far, multiple mechanisms of action of ribavirin have been described
Mechanisms of action of ribavirin in antiviral therapies Antivir Chem Chemother
This article will review proposed mechanisms of ribavirin activity, along with their supporting data, covering ribavirin's roles in the direct inhibition of hepatitis C viral
Mechanism of Action
Five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin
Ribavirin is one of the two approved therapies for the treatment of RSV respiratory tract infections
Examining the effect of ribavirin in the RSV system using microarray techniques, Zhang et al
Reversal of the in vitro antiviral activity by guanosine or xanthosine suggests ribavirin may act as an analogue of these cellular metabolites
1 Hepatitis Intro: Respiratory syncytial virus (RSV) is a common virus that can cause infection in the immunocompromised population
MEDICATIONS for RSV: DRUG NAME: ribavirin: palivizumab (Synagis) CLASS: Antiviral: Monoclonal antibody: MECHANISM of ACTION: Ribavirin is a purine nucleoside analogue whose phosphorylated form resembles the natural nucleotides present in the cells
Food and Drug Administration in 1986 for use as an aerosol for infants with serious infections due to respiratory syncytial virus
RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucleoprotein (RNP) complex
The median treatment duration was 10 days (range: 7-12)
IMPDH inhibition was proposed as the mechanism of action of ribavirin shortly after its discovery
Pharmacokinetics 12
Ribavirin for inhalation has a separate package insert, which should be consulted if ribavirin inhalation Historically, it was believed that the main mechanism of action of ribavirin against a number of RNA viruses (HCV, Respiratory Syncytial Virus (RSV)) is the inhibition of inosine-5'-monophosphate dehydrogenase and the associated decrease in the level of GTP which is required for translation, transcription and replication of the genome
Viruses cause many diseases in humans, from self