BCS is one of the accepted criteria used to grant biowaiver (waiver of in vivo bioequivalence studies) of new drug products
Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition
TLDR
But oral delivery could not be an automatic choice for some drugs with high first-pass metabolism susceptibility
Form/Route: Orally Disintegrating Tablet/Oral
Donepezil hydrochloride (DH) is the most used anti-Alzheimer's disease drug, however, its classification according to the Biopharmaceutics Classification System (BCS) is not clear in the literature
69%) in Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor primarily utilized for treating Alzheimer disease
Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical Donepezil Hydrochloride BCS Class Ambiguity: Relevant Aspects to be Considered in Drug Classification
According to the BCS, drug substances are classified as follows: Class 1: High Solubility—High Permeability Class 2: Low Solubility—High Donepezil hydrochloride (DH) is the most used anti-Alzheimer's disease drug, however, its classification according to the Biopharmaceutics Classification System (BCS) is not clear in the literature
The mean highest concentration of CLZ (C max) and the area under the serum concentration-time