The combination of niacin and simvastatin had important clinical benefits
We recently reported studies in 74 men and 72 women intolerant to ≥2 statins because
Niacin (vitamin B-3) is very common in a Western diet
We analyzed the serum levels of vitamin D in statin-treated patients with
Cholestyramine (Cholybar®, Questran®) – used to lower high cholesterol levels in the blood
When compared to the placebo group, the participants who took both the vitamin D supplement and simvastatin had a greater decrease in their number of
The vitamin D family is a group of fat-soluble secosteroids that regulates calcium and phosphate concentrations and bone mineralization, with cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2 Vitamin D is crucial for mineral metabolization and is said to target over 2000 human genes
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Patient specific characteristics and statin trial history can help assess the importance of obtaining vitamin D levels to help manage patient therapy
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Cells use it to generate energy
Low vitamin D concentrations may be considered a modifiable risk factor for muscle-related adverse effects of statins
Older adults on statin therapy had significantly higher serum 25 (OH)D concentrations
This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue
Experiencing nausea, vomiting or diarrhea
Vitamin CoQ10 is the most important vitamin for our cells to create energy (ATP)
Moreover, an effect of statins on vitamin D metabolism has been suggested as an additional mechanism of action by which statins may exert pleiotropic effects
A portion of this decrease is related to the decrease in the levels of its lipoprotein transport carriers, which is induced by the therapeutic effect of the statins
“From a cardiovascular perspective, I strongly recommend patients treated with statins also have The authors describe a 57% higher risk of cardiovascular disease events (220 events) in the highest tertile (reflecting relative functional vitamin K deficiency), compared with the lowest tertile of dephosphorylated‐uncarboxylated Matrix Gla protein