Commonly used antimicrobials, such as macrolide antibiotics and azole antifungals, interact significantly with the CYP3A4 enzyme pathway similarly to
The aim of this study was to investigate the incidence of coprescriptions involving statins and to compare the exposure of outpatients and
A clinically significant interaction between warfarin and simvastatin is unique to carriers of the CYP2C9*3 allele
Does Simvastatin Have a Unique Risk for Drug Interactions? Although all statins may be affected by drug interactions, simvastatin is exceptionally sensitive for several reasons
Applies to: clarithromycin and simvastatin
2012; 13:757–762
This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue
This medicine may help prevent medical problems (eg, heart or blood vessel problems, heart attacks, or strokes) caused by clogged blood vessels
Avoid combinations; the risk of the interaction outweighs the benefit
Recent Findings In addition to statin utilization increasing in recent years, there is greater emphasis on using moderate to high-intensity statin doses
It can also raise your risk of low blood glucose, low blood pressure, and bleeding if you take it with other medications that have these effects
Always consult your healthcare provider before starting or stopping any medication
Grapefruit and grapefruit juice
The relevance of a particular drug interaction to a specific individual is difficult to determine
Moderate reduction of LDL-C desired: 5-10 mg PO qDay in the evening; adjust dose to achieve goal
4–6 The consequences of this interaction can have potentially serious outcomes and be detrimental to patient well-being
The relevance of a particular drug interaction to a specific individual is difficult to determine
High Cholesterol, Familial Homozygous
But Tamiflu doesn’t interact with other vaccines
Talk to your doctor if you have any questions or concerns
Both potassium-sparing diuretics and lisinopril can increase potassium levels in your blood
Always consult your healthcare provider before starting or stopping any medication