It is not known to have many side effects, although there is the potential for a decreased appetite
Mebendazole acts by binding tubulin in parasitic worms, which it does with greater avidity than the tubulin in mammalian cells, but some of the toxicity of the benzimidazoles may be related to this tubulin-binding activity
Diseases of the Gallbladder and Bile Duct
Abstract Mebendazole (MBZ) is an efficacious anthelmintic with known anti-inflammatory and fibrinolytic properties
Abstract The effect of repeated and exaggerated mebendazole administration was evaluated in dogs with and without experimentally induced altered liver function
Cats in group A were given mebendazole Not approved for use in cats
What is new and conclusion: This is the first case report of important liver injury after administration of MBZ in a patient with Gilbert's syndrome
B The percentage of MDA-MB-231 cells in each phase of cell cycle was determined after treating the cells for 48 h with MBZ Toxicosis, including lethargy, hemorrhage, and death were reported in 13 cases involving pet rabbits, especially in association with high doses or prolonged administration
The LiverTox site is meant as a resource for both physicians and patients as well as for clinical academicians and researchers who Based on the evidence summarised in Table 1, it is our contention that human clinical trials of mebendazole in a range of cancer types is warranted
As with albendazole for dogs, albendazole for cats is considered a relatively safe drug
Acute Toxicity and Tolerance of Fenbendazole
Mebendazole is rapidly metabolized to less toxic metabolites by the liver, and this could be another reason for its low toxicity (Ref
Inactive ingredients are: colloidal silicon dioxide, corn starch, hydrogenated vegetable oil, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, sodium saccharin, sodium starch glycolate, talc, tetrarome The plasma protein binding of mebendazole is 90 to 95%
The prolonged treatment course with elacridar and mebendazole increased toxicity in mice, poorly defined liver metastases: Mebendazole: 100 mg b
Mebendazole is usually well tolerated
Vet Clin North Am Small Anim Pract 23 (3 Toxicity and Tolerance of Milbemycin Oxime
5 mg/kg milbemycin oxime on 3 consecutive days, repeated during 10 months without undesirable side effects
However, it is recognized that the metabolic system of cats is unique when compared e
Chemical structures of MBZ and other benzimidazole anthelmintics commonly prescribed for human (Albendazole, ABZ) and veterinary (Fenbendazole, FBZ, and Flubendazole) use are shown in Figure 1
106 mg/kg; LD50 acute, rat, dermal >2000 mg/kg; In dogs without the MDR-1 gene defect a single oral dose of 1120 mcg/kg, 300x the therapeutic dose as a heartworm (Dirofilaria spp) preventative, caused no undesirable adverse drug reactions
In addition, dog medicines may sometimes contain ingredients that are toxic to cats
Baral, in The Cat, 2012 Fenbendazole
Fenbendazole binds beta-tubulin subunits of Dogs: NEL (no effect level) in 1-year chronic toxicity studies was 0
c
Molecular formula
Dose (against mebendazole-susceptible parasites) Oral
25 g / 8 kg
The prolonged nature of maintenance therapy requires minimal or tolerable toxicity to be feasible
Mebendazole and oxibendazole have caused acute hepatic injury in dogs and are generally no longer used in this species
Liver disease in cats has numerous causes, which often makes determining the source frustrating for veterinarians
Mebendazole is approved for human consumption by the FDA, while fenbendazole is only approved for veterinary use and has not been approved for human use
Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its WHO Acute Hazard classification: Not listed
It works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies
131 mg/kg LD50 acute, rats, dermal >5000 mg/kg As a general rule, dogs and cats tolerate imidacloprid very well
Infections 100 mg chewable tablet: 100 mg orally twice a day (morning and evening) for 3 consecutive days
Mebendazole has a better toxicity profile than albendazole and a long track record of safety in humans, which makes it the favorite candidate for clinical trials
Mechanism of action of Mebendazole
TECHNICAL SUMMARY of MEBENDAZOLE, anthelmintic for veterinary use in DOGS and CATS, HORSES, PIG, POULTRY and other livestock, against
The following symptoms may be observed in cats with liver toxicity: Loss of appetite Severe physical discomfort Vomiting Diarrhea Jaundice (often progressive)
Diseases of the Gallbladder and Bile Duct
However, treatment must be given for 3 days
Seyed Mahdi Hassanian Scientific Reports 12, Article number: 10249 ( 2022 ) Cite this article 3638 Accesses 6 Citations 1 Altmetric Metrics Abstract Mebendazole
Mebendazole induces G2/M cell cycle arrest and apoptosis
for 6 wk No chronic effects with 3–30 mg/kg for 98 days in rats and dogs: No teratogenicity in mice, rats, sheep at 30 mg/kg and cattle at 75 mg/kg during pregnancy Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm (pinworm), and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract
Over 28,000 peer-reviewed resources: Bovis, Equis, Felis, Lapis & Exotis
After the first pass in the intestinal wall and liver, the metabolites are active against parasites in internal organs and tissues [47,48]
o
Current Indications and Safety
[1] DILI can be classified based on clinical presentation (hepatocellular, cholestatic, or mixed), mechanism of hepatotoxicity, or histological appearance from a liver biopsy
Vomiting (~4%) Dry skin (~3%) Diarrhea (~3%) Lethargy (~1
Twenty five healthy cats were randomly allotted into five equal groups
The aim of this study was to determine the protective action of silymarin on mebendazole-induced hepatotoxicity in cats
106 mg/kg; LD50 acute, rat, dermal >2000 mg/kg; In dogs without the MDR-1 gene defect a single oral dose of 1120 mcg/kg, 300x the therapeutic dose as a heartworm (Dirofilaria spp) preventative, caused no undesirable adverse drug reactions
c
Digestive System, Liver, and Abdominal Cavity
Although mebendazole kills adult worms, it does not kill the eggs
Molecular formula
The prolonged nature of maintenance therapy requires minimal or tolerable toxicity to be feasible
It is not known to have many side effects, although there is the potential for a decreased appetite
Dosing recommendations for MEBENDAZOLE