Mar 28, 2006 · Abstract Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells
Among clinically used medicines with no or little toxicity, fenofibrate is a drug of the fibrate class that plays an important role in lowering the levels of serum cholesterol and triglycerides while elevating the levels of high-density lipoproteins
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PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway | Acta Pharmacologica Sinica Article Cumulatively, evidences revealed that fenofibrate used in the therapy of hyperlipidemia and hypercholesterolemia has anti-cancer effect in multiple cancer types
Fenofibrate inhibits breast cancer cells proliferation
DNA content analysis shows that G1/S phase progression through the cell cycle is inhibited
Title: Fenofibrate-promoted chemosensitivity is predominantly mediated by caspase-9 and caspase-3 activation and mitochondrial outer membrane permeabilization
5, 25, 50, 100, 200, and 400 µM fenofibrate were used to treat MGC803 and SGC7901 cells for 24 h
The experiments were repeated three times and the Fenofibrate, an Old Lipid Drug is also an Anti-Cancer Drug
Learn about the side effects, uses, dosage, interactions and warnings of fenofibrate on RxList
Fenofibrate activates an enzyme called lipoprotein lipase which increases the breakdown of lipids and the elimination of triglyceride-rich particles from the blood
pains in the stomach, side, or abdomen, possibly radiating to the back
Here we tested whether fenofibrate can improve the efficacy of a cancer vaccine if the drug is given directly to tumor-bearing mice
Studies found fenofibrate exerted anti-tumor roles in various human cancer cell lines
Keywords: cachexia; fenofibrate; glucocorticoids; ketones; skeletal In healthy subjects, berberine did not increase side effects when used in combination with simvastatin or fenofibrate
Fenofibrate inhibited the cell migration and invasion of CAL 27 cells by the wound healing and Boyden chamber transwell assays, respectively
Its induction of apoptosis was independent on PPAR-α status with the highest apoptosis Fenofibrate, a common drug used to treat severe hypertriglyceridemia and mixed dyslipidemia, reversed cellular metabolism and mitochondrial dysfunction in gastric cancer cells through PPARα
As a metabolic blocker, fenofibrate interferes with cancer promotion/progression via its misbalancing effects on cellular metabolism
We observed differential effects on cell proliferation in A549 and SK-MES-1 lung cancer cells by budesonide and fenofibrate
Indications and dose For fenofibrate Adjunct to diet and other appropriate measures in mixed hyperlipidaemia if statin contraindicated or not tolerated, Adjunct to diet and other appropriate measures in severe hypertriglyceridaemia, Adjunct to statin in mixed hyperlipidaemia if triglycerides and HDL-cholesterol inadequately controlled in patients at high cardiovascular risk for fenofibrate Fenofibrate, a PPARα agonist, is wildly used to treat hypercholesterolemia and hyperlipidemia, and also has been repurposed as an anti-cancer agent
Lampidis, Professor of Cell Biology at the University of Miami Miller School of Medicine, today announced a major breakthrough that paves the way for a viable non-toxic treatment of a wide variety of cancers
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do
Indeed, there is a positive correlation between ATM and PPARα in both cell lines and HGSOC patient samples (Figure 3 A, B), suggesting that ATM-low cancers have low PPARα, which may be therapeutically exploited using fenofibrate
Fenofibrate is the most widely used lipid-lowering drug, but it seems to have anti-tumor effects in several tumor cell lines
The PPARA agonist, fenofibrate, might serve as an applicable agent for Fenofibrate may cause other side effects
By contrast, the incidence in the non-Western world is approximately ten-fold lower []
Common side effects include liver problems, breathing problems, and stomach pain
It is widely utilized in therapy of hyperlipidemia and hypercholesterolemia
Using this model, we Fenofibrate, an agonist of PPAR-alpha, in doses above 25 microM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells
A review by Lian and colleagues lists 25 in vitro studies of fenofibrate's anti-cancer activity in 12 different cancer types, including two relating to HPV− HNSCC
Fenofibrate is a fibric acid derivative which exhibits a role of How to cite this article: Koltai T
3390/cancers10100363
Peroxisome proliferator-activated receptor alpha (PPARA) is the molecular target of fibrates commonly Fenofibrate failed to confer anti-cancer activity (Extended Data Fig
In addition, pretreatment of fenofibrate combined with radiation significantly suppressed cell migration and invasion in pancreatic cancer cells
In addition, both salicin and fenofibrate were shown to be cytotoxic to MCF-7 and Panc-1 cell lines through activation of the caspase 3/7 It is found that fenofibrate inhibited the viability of human pancreatic cell lines in a dose-dependent manner by an MTT assay and pretreatment combined with radiation suppressed cell migration and invasion in pancreatic cancer cells
Abstract
These results demonstrate how targeting hepatic metabolism can prevent muscle wasting in lung cancer, and provide evidence for a therapeutic strategy
Fenofibrate is a lipid-lowering drug with potential anti-tumor properties, which is claimed with suppressive effects on OPN expression
Objective: Extravasation of circulating cancer cells is an important step of the metastatic cascade and a potential target for anti-cancer strategies based on vasoprotective drugs
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There is no evidence to support that it increases Fenofibrate is also the preferred fibrate in patients who require combined therapy with a statin and fibrate
Next, we examined whether combined treatment of fenofibrate and paclitaxel, TRAIL, ABT-737, and doxorubicin exerts enhanced lethality in human breast cancer cell lines
Among them, 454 (1
Recently, fenofibrate has been shown to inhibit the growth of several kinds of cancer cells
cachexia | skeletal muscle | glucocorticoids | ketones | fenofibrate The cancer anorexia cachexia syndrome (CACS) is a combined effects of rosuvastatin and fenofibrate on prostate cancer, Ischemic stroke and hypolipidemia
A 63 years old male with hypertriglyceridemia developed symptoms of fatigue and Fenofibrate (Oral Route) Fenofibrate is used together with a proper diet to reduce and treat high cholesterol and triglyceride (fat-like substances) levels in the blood
One trial compared fenofibrate to bezafibrate and reported a similar effectiveness in ALP reduction , although fenofibrate was superior in reducing serum LDL and uric acid levels
" Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease ( pancreatitis )
32, 33 Bioavailability has been greatly improved with advances in drug design and therefore, the effective dose depends on the Fenofibrate exerts an anti-proliferative property by inhibiting the expression of AR and induces apoptosis by causing oxidative stress
While statins have strong evidence for reducing heart disease and death Abstract
Recent studies have shown that fenofibrate can inhibit the growth of several cancer lines and hypoxia-inducible factor-1α (HIF-1α) expression in MCF-7 cells
In addition, fenofibrate reduced the protein expressions of MMP-1, MMP Fenofibrate decreased prostate cancer cell survival as indicated in Fig
We further discovered that fenofibrate reduces the activity of pro-metastatic enzymes, matrix metalloproteinases (MMP)-9 and MMP-2
Human colon adenocarcinoma specimens had lower levels of PPARA and retinoblastoma protein and higher levels of DNMT1 and PRMT6 than Fenofibrate, originally marketed as Tricor, reduces both triglycerides and bad cholesterol or LDL while simultaneously boosting good cholesterol or HDL
5·9% (n=288) of patients on placebo and 5·2% (n=256) of those on Given the great potential that fenofibrate may have anticancer effects, this review was to investigate all published works which directly or indirectly support the anticancer activity of fenofibrate
However, the mechanism underlying these effects remains to be elucidated
Multifunctional nanocrystals for cancer therapy: a potential nanocarrier
3 Tricor
Based on exclusion of other disease etiologies and a positive drug rechallenge, fenofibrate fits as a class 1A medication in the classification of drug-induced pancreatitis
fenofibrate) with chemotherapeutic drugs interfere with the drug-resistance of prostate cancer cells
ATM-low cancer cells are slightly, although significantly more sensitive to fenofibrate (Figure 2), suggesting that these cells may have low PPARα signaling
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Therefore, fenofibrate may be a promising therapy to prevent radiation-induced brain injury and improve the quality of life of cancer patients receiving brain irradiation
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In Egypt, breast cancer is the most common malignancy in women In B16 F10 cells transiently overexpressing PPARa, fenofibrate was also able to trigger ketogenesis (Figure 2 A)
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Incubation with the synthetic PPARa inhibitor MK886 did not reverse this effect (Figure 2A)
Here, we report a novel observation that fenofibrate, a synthetic peroxisome proliferator-activated receptor alpha (PPARa) agonist, induces bHB production in melanoma and glioblastoma cells, as well as in neurospheres composed of non-transformed cells
The purpose of this study was to investigate the radiosensitivity enhancement effects of fenofibrate combined with radiation on the human esophageal carcinoma Fenofibrate tablets USP should be given with meals, thereby optimizing the bioavailability of the medication
Additionally, fenofibrate impaired tumor growth as monotherapy and potentiated the activity of cisplatin in a pre-clinical HPV+ animal model
Some PPARα-specific agonists, such as Wy14643 and fenofibrate, have been applied in metabolic syndrome treatment, which might own potential in wider application
High PPAR activity can kill cancer cells that are unable to However, fenofibrate at daily low doses (25 mg/kg or 0
Results from a randomized clinical trial show that treating patients with COVID-19 with fenofibrate has no significant effect istradefylline will increase the level or effect of fenofibrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism
A miRNA microarray revealed that fenofibrate differentially regulated cellular miRNAs with known roles in cancer and angiogenesis
Breast cancer is the most common malignant cancer in women worldwide
Fenofibrate is a hypolipidemic drug, which acts by activating the Surprisingly, the PPARα agonist fenofibrate potently suppressed primary tumor growth in mice
Fenofibrate weakened DNMT1 activity and restored the expression of the tumor suppressor gene, CDKN2A, which suppressed cell proliferation by blocking the G1
1 Altmetric Metrics Abstract This study demonstrated that fenofibrate, a lipid-lowering drug, induced a significant time-dependent cytotoxicity of hepatoma Hep3B
Fenofibrate was found to 3
This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects
Fenofibrate is a widely used anti-hyperlipidemic agonist of peroxisome proliferator-activated receptor alpha (PPARα)