Tolterodine is a newer, selective cholinergic muscarinic receptor antagonist used
This review highlights the design and development of fesoterodine (Toviaz)
Tolterodine tartrate extended-release capsules are associated with
This medicine
Fesoterodine acts as a prodrug and is converted to an active metabolite, 5-hydroxymethyl tolterodine (5-HMT); 5-HMT is responsible for fesoterodine’s antimuscarinic activity and acts as a competitive antagonist of muscarinic receptors
Therefore, these prodrugs could help patients who feel severe pain, since a low volume injection would release high drug concentration upon biotransformation
Fesoterodine itself is a prodrug for the compound 5-hydroxymethyl tolterodine (“5-HMT”)
There are immediate-release (IR) and extended-release
Therefore, acting as a competitive This review highlights the design and development of fesoterodine (Toviaz®) as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), which is also the active metabolite of tolterodine, for the treatment of overactive bladder (OAB)
Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great Fesoterodine fumarate is a prodrug of 5-hydroxymethyl tolterodine (5-HMT), which a muscarinic M2 and M3-receptor antagonist with antispasmodic activity, and is also the active metabolite of tolterodine
Second, Bundgaard and Bundgaard PCT focus on prodrug design principles
, Tolterodine, a New Musca- A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i
Fesoterodine is a prodrug of 5-hydroxymethyl tolterodine (5-HMT), which itself is a metabolite of tolterodine, which is the active ingredient of Detrol®, an antimuscarinic drug used to treat loss of appetite
Acid-stabilized tolterodine L-tartrate may be used as an active ingredient in various types of immediate release and controlled release dosage forms, including tablets, capsules, and beads
4 hours, and the half-life of Descriptions
The Design and Development of Fesoterodine as a Prodrug of 5- Hydroxymethyl Tolterodine (5-HMT Fesoterodine functions as an orally active prodrug that is converted to the active metabolite 5-hydroxymethyltolterodine by non-specific esterases
[3] [4] Promedicamentele sunt Tolterodine is a potent muscarinic receptor antagonist and has been used for the treatment of overactive bladder for over ten years
Fesoterodine free base is an oily liquid and lacks crystalline properties making API-base unsuitable for further pharmaceutical development