Autoimmune hepatitis is a rare immune mediated inflammatory disease of the liver characterized by circulating autoantibodies, increased concentration of IgG, and distinctive histological features
The mainstay of treatment is non-specific immunosuppression, consisting of
Potential adverse effects of azathioprine (AZA), such as neutropenia and hepatotoxicity, make its use in autoimmune hepatitis (AIH) problematic
Background: In most patients with autoimmune hepatitis, remission can be maintained with prednisolone, usually in combination with azathioprine, but the majority
AZA is a prodrug, and the
4% [6 of 39 patients] in the MMF group and 19
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis
Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus and end-stage renal disease
Autoimmune hepatitis is more common among women than men, but it occurs globally in children and adults of both sexes in diverse ethnic groups
6–2
Autoimmune hepatitis (AIH) is an immunoinflammatory chronic liver disease with dynamic and rather heterogeneous disease manifestations
There are many forms and causes of hepatitis (such as viruses and certain drugs), including autoimmune hepatitis (AIH)
Azathioprine (AZA) is a part of the standard therapy for autoimmune hepatitis (AIH); however, there are crit- Autoimmune hepatitis is a chronic disease of unknown cause, characterized by continuing hepatocellular inflammation and necrosis and tending to progress to cirrhosis
AZA‐induced leukopenia patients with autoimmune disorders were enrolled from multiple medical centers in Taiwan/China between 2012~2017 to determine the strength of genetic association of NUDT15 Abstract
4%) had leukopenia
It induces clinical, laboratory and histological remission in 80% of patients within 3 years[2,4]; the 10- and 20-year life expectancies of treated patients exceed 80%[5-7]; hepatic fibrosis is reduced or prevented in 79%[8,9];
Recent epidemiological
Doctors have identified two main forms of autoimmune hepatitis