Valproic acid can be eliminated with the use of high-flux HD followed, if
We review the indications for hemodialysis for removal of specific toxins
The relatively low molecular weight (144 Daltons) and low volume of
Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders
Successful Treatment of Valproic Acid Overdose With Hemodialysis
[PMID: 11054983] / Sztajnkrycer MD
Do not combine with mefloquine (increased risk of seizures)
If valproate is to be used during pregnancy, the lowest effective dose should be prescribed in divided doses to avoid peaks in plasma-valproate concentrations; doses greater than 1 g daily are associated with an increased risk of teratogenicity
1996;34(3):335-341
Life-threatening valproic acid toxici
Phenobarbital
0 80-320mg PO Q24H, (N/A) Administer anytime during HD; Dose post HD if
Valproic acid (VPA) is an approved treatment for seizure disorders and recommended by a recent Cochrane review ()
Hemodialysis is a therapeutic option managing hyperammonemia
Valproic acid concentration in saliva is less than and unrelated to the free drug concentration in plasma
During hemodialysis, the free fraction increased significantly (p less than 0
Although valproic acid (VPA) has been recently shown to induce autophagy, the effect of VPA-induced autophagy on renal fibrosis remains unknown
@article{Johnson1999SuccessfulTO, title={Successful treatment of valproic acid overdose with hemodialysis
Background: The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning
(F) ImageJ software was used for the Although valproic acid (VPA) induces the metabolism of multiple other drugs, the clinical reports of VPA autoinduction are rare
Valproic acid leads to hyperammonemia by increasing serum propionic acid levels, which inhibits carbamoyl phosphate synthase, a rate-limiting enzyme in the metabolism of ammonia via the urea cycle
Of these, 30% (5046) were treated in a health care facility with 12 cases resulting in death