OBJECTIVE:To assess the comparable efficacy and adverse effect profile of two extended-release preparations of nifedipine — Gastrointestinal therapeutic system
Nifedipine coat-core is a modified-release formulation of nifedipine, which means that the medication is released slowly over time
Conclusions: These data suggest that long-term treatment with valsartan could reduce arterial stiffness better than nifedipine-coat core
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Since calcium channel blockers are well-tolerated and efficacious in African Americans, we undertook this study to compare the efficacy, safety, and tolerability of 3 commonly prescribed calcium channel blockers: amlodipine besylate (Norvasc)
Both contain nifedipine, the coat as a slow release formulation and the core as a fast release formulation
In this group of patients with mild hypertension, there were no clinically relevant differences in blood pressure control between the two forms of nifedipine
During the study period, 59 (65
60, respectively
After 2 weeks of placebo twice daily, 36 patients were randomized to receive either nifedipine retard 20 mg twice daily (R40) or nifedipine coat-core 60 mg once daily (CC60), double-dummy for 2 weeks
Both contain nifedipine, the coat as a slow release formulation and the core as a fast release formulation
Grant number: 5 U01FD005946
of nisoldipine minimises negative inotropic effects which may be observed with less selective agents such as nifedipine Nisoldipine coat-core is a long-acting formulation of the dihydropyridine calcium antagonist (calcium channel blocker) nisoldipine, suitable for once daily administration in the treatment of patients with hypertension
Coadministration of nifedipine 10 mg capsule and 60 mg nifedipine coat-core tablet with phenytoin, an inducer of CYP3A, lowered the AUC and C max of nifedipine by approximately 70%