Once-daily oral daclatasvir plus sofosbuvir was associated with high rates of sustained virologic response among patients infected with HCV genotype 1, 2, or 3
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Approved indication: hepatitis C
In summary, daclatasvir is a hepatitis C virus, non-structural protein 5a-selective inhibitor with a well-characterized pharmacokinetic profile that forms part of potent and well
EMA/458670/2017 Page 2/3 How does Daklinza work? The active substance in Daklinza, daclatasvir, blocks the action of a protein in the hepatitis C virus called ‘NS5A’, which is essential for the virus to multiply
There is a lack of data pertaining to the reactivation risk during DAA treatment in those coinfected patients
The treatment of patients infected with the hepatitis C virus (HCV) has been revolutionised by the development of direct-acting antiviral agents (DAAs) that target specific HCV proteins involved in viral replication
Daklinza is a medicine that contains the active substance daclatasvir, which is used to treat chronic hepatitis C infection in adults
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(NYSE:BMY) said EMA accepted for review and granted accelerated assessment to an MAA for daclatasvir ( BMS-790052) to treat HCV infection in patients with compensated liver disease, including HCV genotypes 1, 2, 3 and 4 infection
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Medicinal product by therapeutic areas/Possible Mechanism of Interaction
1 It was made available by the European Medicines Agency (EMA) for compassionate use in November 2013
DCV daclatasvir, EBR elbasvir, GLE glecaprevir, GZR grazoprevir, For daclatasvir, embryofoetal toxicity (external and/or visceral malformations) in rabbits and rats was reported by the EMA
(NYSE:BMY) said EMA accepted for review and granted accelerated assessment to an MAA for daclatasvir ( BMS-790052) to treat HCV infection in patients with compensated liver disease, including HCV genotypes 1, 2, 3 and 4 infection
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This article provides a narrative review of the efficacy and tolerability of daclatasvir in combination with other agents in the treatment of patients with chronic HCV infection and summarizes its