The ARMYDA-6 MI trial authors randomized 201 patients undergoing primary PCI for STEMI to 600 mg (n = 103) or 300 mg (n = 98) clopidogrel loading dose before
However, data for clinical superiority are limited, and
Background: Clopidogrel/aspirin antiplatelet therapy routinely is administered 7-10 days before pipeline aneurysm treatment
The primary outcome of major ischemic events (the composite of ischemic stroke, myocardial infarction, or death from an ischemic vascular event) occurred in 5
The ARMYDA-6 MI trial authors randomized 201 patients undergoing primary PCI for STEMI to 600 mg (n = 103) or 300 mg (n = 98) clopidogrel loading dose before the procedure
Patients receiving 600-mg loading dose of clopidogrel showed a significantly lower incidence of post-PCI myocardial blush grade 0 or 1 (odds ratio 0
Patients treated with fibrinolytic therapy: Give clopidogrel loading dose 300 mg if age 75 years or less; if age over 75 years, Clopidogrel may be given in a dose of 300 to 600 mg, but we prefer 600 mg
Transitioning from ticagrelor: Give a clopidogrel 600 mg loading dose 12 hours after the last dose of ticagrelor, followed by 75 mg once daily (Franchi 2018)
Clopidogrel 300 mg is the licensed loading dose however the EPAR states that a higher, 600 mg dose has been shown to be more effective and this is advocated in ESC guidelines
Current guidelines advocate clopidogrel bridging with a 600 mg loading dose (LD)
Acute ischemic stroke patients presenting consecutively to our center from 07/01/08 to 07/31/13 were screened
In patients undergoing PCI, a 600-mg loading dose should be administered before the procedure, followed by 75 mg once daily for at
If switching in an acute setting, loading doses are always recommended
We evaluated the effect of high versus low loading doses of clopidogrel in patients with stable angina pectoris who underwent percutaneous coronary intervention (PCI) on periprocedural events, in-hospital complications, and 30-day outcomes