Serotonin syndrome
for migraine, triptans, like sumatriptan for depression, selective serotonin reuptake inhibitors (SSRIs), like fluoxetine, citalopram, sertraline and paroxetine, and selective
It is caused by medications that build up high levels of serotonin in the body
, SSRIs) can excessively
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter (Fig
To make sure Imitrex is safe for you, tell your doctor if you have ever had: liver or kidney disease;
You may keep a headache diary to record your headache frequency and drug use
The concurrent use of sumatriptan with an SSRI or lithium has been reported to cause symptoms suggestive of serotonin syndrome in 16 and 2 cases, respectively
Serotonin syndrome symptoms include agitation, blood pressure change, fever, rapid heart rate, seizures and twitching muscles
It works by narrowing blood vessels in the head, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine
Serotonin syndrome happens when you have too much serotonin in your body
In the past, doctors were concerned about the risk of serotonin syndrome when triptans were taken together with medications that impact serotonin, like many antidepressants
Ann Pharmacother
Most common adverse reactions (≥2% and >placebo) were paresthesia, warm/cold sensation, chest pain/tightness/pressure and/or heaviness, neck/throat/jaw pain/tightness If you take Imitrex with one of these antidepressants, it could raise your risk for a side effect called serotonin syndrome
Includes SUMAtriptan indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more
serotonin syndrome
(1) Limitations of Use: Use only if a clear diagnosis of migraine headache has been established
sumatriptan (generic) +
If concomitant treatment with sumatriptan and an SSRI/SNRI is clinically warranted, appropriate observation of the patient is advised (see section 4
Serotonin syndrome is caused by having too much of the neurotransmitter serotonin in your body, which can be fatal