It is characterized by sudden and severe attacks of joint pain, swelling, and redness, often targeting the big toe
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Usual Adult Dose for: Gout
Dosing should be increased every two to five weeks to reduce serum urate levels to 6
In people with kidney problems, it may be even lower
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Your doctor may adjust your dose as needed
What is allopurinol? Allopurinol is used for the long-term treatment and prevention of gout
For many people, allopurinol 300 mg daily will be insufficient to achieve target serum uric acid reductions
Until recently, the last drug approved for the treatment of gout by the United States Food and Drug Administration was allopurinol in 1966
and treatment with allopurinol, febuxostat, and uricosuric agents are insufficient to achieve Allopurinol is used to treat gout (a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and heat in one or more joints)
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A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation)
Get a detailed overview of allopurinol for gout, including possible side effects of allopurinol, recommended dosages for allopurinol, how much allopurinol costs, and what allopurinol is used for
Allopurinol is preferred over drugs such as probenecid or sulfinpyrazone because it decreases the amount of uric acid excreted in the urine and thus discourages
Group 1: allopurinol starting dose 100 mg daily that increased by 100 mg each week to 300 mg daily
2 3 The BSR guideline suggests starting allopurinol 50–100 mg daily, increased in 100 mg increments every four weeks (maximum 900 mg/day) until target serum uric acid level has been achieved
Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout 6
Treatment is stopped once the attack is over, and symptoms have gone away
Colchicine has a narrow therapeutic range and its use Once allopurinol has been initiated, regular follow-up with serum urate testing is required while the dose of allopurinol is titrated upwards, until the serum urate target is reached
However, taking the drug colchicine for the first six months of allopurinol therapy can help prevent the attacks, he says
Allopurinol ( Aloprim, Zyloprim) reduces uric acid production
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Cautions, further information
However, allopurinol is often mismanaged, and prescribed without reference to frequent uric acid test results
What are the long-term side effects of allopurinol? Allopurinol is considered a safe, long-term treatment for gout
A member of a drug class called xanthine oxidase inhibitors (XOIs), this medication, taken orally each day, reduces the body’s Gout, treatment (chronic urate-lowering therapy): Oral: Note: Patients with renal impairment should be carefully monitored during the early stages of allopurinol treatment; reduce the dose or withdraw therapy if increased renal function abnormalities appear and persist
These include losing weight (if overweight), eating a healthy diet and not drinking much alcohol or sugar-sweetened soft drinks