This article outlines the indications, action, and contraindications for digoxin as a valuable agent in managing heart failure and certain arrhythmias
125 mg once daily; CrCl 30-80 mL/min—0
Abstract
7 Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954
Digoxin belongs to the class of medicines called digitalis glycosides
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Digoxin also has numerous other drug interactions The judge also denied Giri's motion to certify the lawsuit as a class action
Vibegron increases digoxin maximal concentrations and systemic exposure
Immunoglobulin fragment with a specific and high affinity for both digoxin and digitoxin molecules
In 1930, Wolff, Parkinson, and White described a series of young patients who experienced paroxysms of tachycardia and had characteristic abnormalities on electrocardiography (ECG)
Advanced therapies should be considered after right-sided heart catheterization for PAH patients in functional class II, III, or IV
Using the right drug: a treatment algorithm for regular supraventricular tachycardias
Reimold SC
Class II: Slight limitation of physical activity
pacritinib will increase the level or effect of digoxin by P-glycoprotein (MDR1) efflux transporter
Use Caution/Monitor
Indapamide belongs to a class of drugs known as diuretics/"water pills
Monitoring of appropriate chemistry study results to determine dosages and the occurrence of adverse effects
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Use with other drugs metabolized by CDA may increase levels and toxicities of those drugs
Use of oxaliplatin with concomitant immunosuppressants or with impaired immune systems may increased risk for serious infections
Avoid or Use Alternate Drug
Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis
digoxin
25 mg q12hr and to a maximum dose of 2
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Compare formulary status to other drugs in the same class
Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis
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25 mg with a combination of solifenacin 5 mg and mirabegron 50 mg increased digoxin AUC and peak plasma concentration by ~10% and 14%, respectively Adding plans allows you to compare formulary status to other drugs in the same class
Avoid or Use Alternate Drug
Digoxin and adenosine alter the electrophysiologic mechanisms responsible for arrhythmia
These drugs cause diuresis to decrease plasma volume and edema and thereby decrease cardiac output and, consequently, blood pressure
lansoprazole will increase the level or effect of digoxin by increasing gastric pH
ozanimod
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See more Drugs & Diseases digoxin immune FAB (Antidote) (Rx) Brand and Other Names: Digibind, DigiFab Classes: Antidotes, Other Dosing & Uses AdultPediatric Dosage Forms &
Blockade of efflux of sodium increases calcium in
Generic name: digoxin (oral/injection) [ di-JOX-in ] Brand names: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin Drug classes: Group V antiarrhythmics, Inotropic
Medscape - Indication-specific dosing for Digibind, DigiFab (digoxin immune FAB (Antidote)), frequency-based adverse effects, comprehensive interactions
Remember that
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Easily compare tier status for drugs in the same class when considering an alternative drug for your patient
The New York Heart Association (NYHA) classification system categorizes heart failure on a scale of I to IV, [ 2] as follows: Class I: No limitation of physical activity
The system classifies the medications according to the primary mechanism of action (although several agents retain properties from multiple classes)
The safety of drugs for supraventricular tachycardia
Hold your breath for ≤10 sec; before breathing out
Initial: 5 mg PO BID with 20-50 mcg/kg/min IV (high dose): May increase blood pressure and stimulate vasoconstriction; may not have a beneficial effect in blood pressure; may increase risk of tachyarrhythmias
bisoprolol increases and levalbuterol decreases serum potassium
sucralfate will decrease the level or effect of digoxin by inhibition of GI absorption
ozanimod increases toxicity of dobutamine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate
Monitor for increased alprazolam side effects including drowsiness or fatigue, nausea, vomiting, diarrhea or constipation
[ 2] Therapeutic levels of digoxin are 0
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ampicillin will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora
Disclosure: Nothing to disclose
Calcium gluconate dosing, indications, interactions, adverse effects, and more
Class IIa: Reasonable : PMBC for asymptomatic patients without unfavorable clinical characteristics when the risk of thromboembolism or hemodynamic decompensation is high : Class IIa: Reasonable
Withdrawal of the offending drugs is the first treatment for heart block
5 mg/day
Indicated to reduce risk of stroke in patients with acute ischemic stroke (NIH stroke scale score ≤5) or high-risk transient ischemic attack (TIA) Loading dose: 180 mg PO x 1 dose
Too-rapid correction of hyponatremia (eg, >12 mEq/L/24 hr) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma, and death