It is usually taken with or without food twice a day (every 12 hours) for 10 to 28 days
You should carry sugar tablets with you when taking linezolid (Zyvox) in case you need a sugar boost
Patients must have met one of the following UTI definitions: (1) > 10 5 CFU/mL of VRE growth with no invasive catheter use < 48 h before culture, and at least
less than 5 yrs: 10 mg/kg oral ‡ every 8 hours 5–11 yrs: 10 mg/kg oral ‡ Adults: 400 mg oral ‡ every 12 hours Adolescents: 600 mg oral ‡ No dose adjustment is necessary when
For children, the dosage is also based on age and weight, and they may be directed to take this medication every 8 hours
every8hours 600 mg intravenously or oral窶。 every12hours 14 to 28 Uncomplicated skin and skin structure infections less than 5 yrs: 10 mg/kg oral窶。 every8hours 5-11 yrs: 10
Dosage forms: intravenous solution (2 mg/mL-D5%; 2 mg/mL-NaCl 0
10 mg/kg every 8 hours HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ZYVOX safely and effectively
The potential for drug-drug interactions with linezolid and the antioxidants Vitamin C and Vitamin E was studied in healthy volunteers
16 to 18 years: 2 grams via IV injection over 30 minutes every 8 hours
The purpose of this study was to determine if a difference in efficacy or safety exists between linezolid and non-linezolid treatments for VRE UTIs
The main uses are infections of
There were 79 patients randomized to high-dose linezolid and 66 to low-dose linezolid
Vancomycin Loading Dose + vancomycin 15mg/kg • Linezolid 600mg IV Q12H ± Clindamycin 600mg IV Q8H (use in combination with vancomycin for toxin suppression) Bacterial Meningitis – “Spontaneous” Ceftriaxone 2g IV Q12H Vancomycin Loading Dose + vancomycin 15mg/kg • Ampicillin 2g IV Q4H (>50 year of age OR immunocompromised) Pseudomonas aeruginosa infections of the eye, ear, urinary tract, gastrointestinal tract, and central nervous system; Pseudomonas aeruginosa pneumonia; Pseudomonas aeruginosa skin and soft tissue infections; Urinary tract infections in infants older than one month and children less than two years: Acute management, imaging
Thus there are good concentrations of the active drug present in urine, well above the MICs of potential Gram-positive pathogens
The purpose of this study was to determine if a difference in efficacy or safety exists between linezolid and no
The safety and efficacy of ZYVOX formulations given for longer than
239 l/kg and 0
Not known whether linezolid or its metabolites removed by peritoneal dialysis
Due to a lack of effective oral therapy options, urinary tract infections (UTI) caused by vancomycin-resistant enterococcus (VRE) are difficult to handle
No change to dose - 1 PK study in critically ill, obese patients with SSTI showed suboptimal PK/PD target attainment with 600 mg q12h for MIC ≥ 1 mg/L UTI: up to 320 mg (TMP component) PO BID or
5–11 yrs: 10 mg/kg oral ‡ every 12 hours