The oral glucose tolerance test was performed after an overnight fast, and plasma drawn for mid-dosing interval efavirenz, fasting total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglycerides concentrations
The newer statin rosuvastatin is only marginally metabolised by the CYP3A4 system, with most of the drug being excreted unchanged, and has been used to treat dyslipidaemia in HIV In the pooled dolutegravir analysis, minimal increases in LDL-C and triglycerides were observed but mean values at 48 weeks remained below National Cholesterol Education Program target levels
On multivariable analyses (adjusting for age, sex, body mass index, and ART duration) doubling of efavirenz concentrations resulted in mean changes in mmol/L
When coadministered with statins such as simvastatin
508–0
Efavirenz (Sustiva ®) is a first-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat human immunodeficiency virus (HIV) type 1
Recently, several new antiretroviral
Efavirenz Etravirine: Adjust statin dose according to lipid responses, but do not exceed the maximum recommended dose
Efavirenz is associated with a
Over time, women gained more than men, and weight gain continued to rise over
This ratio is the best guide to the likelihood of future
Primary hepatocytes isolated from Pxr F/F or Pxr ΔHep mice were treated with 20 µM emtricitabine, efavirenz, or PCN for 24 h
High cholesterol increases the risk of heart disease
Some people taking efavirenz have experienced increased levels of lipids (cholesterol and triglycerides) in the blood
It belongs to the class of nonnucleoside reverse transcriptase inhibitors and has the advantage of once-daily dosing
Data are limited on other non-nucleoside reverse transcriptase inhibitors, but the same principle is likely to apply
Others experience some side effects, but these are usually minor, such as diarrhoea , a headache or feeling sick
Background Dyslipidemia represents a significant non-infectious comorbidity among people living with HIV
The primary outcome was the use of lipid-lowering agents including statins, fibrates and fish oil
SIM, ATR, and PRA concentrations were determined before and after EFV, and EFV concentrations were determined before and after statins
Statins
Efavirenz is assessed for activation of cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme that converts cholesterol to 24-hydroxycholesterol