Average adherence rates for key safety
Its metabolism into dapsone hydroxylamine (DDS-NOH) results in hemolysis, and the prevalent theory is that dapsone-induced hemolysis leads to erythrophagocytosis by the reticuloendothelial (RE) system, preventing sequestration and destruction of platelets
Methemoglobin is a form of hemoglobin wherein its heme iron has been oxidized, changing its iron configuration from the ferrous (Fe 2+) to the ferric (Fe 3+) state
Rarely, if dapsone is used for a long time at high doses people can experience reduced function of the nerves in their limbs; causing weakness of muscles in the hands and feet
Maintenance dosage can often be reduced in
Results: This system of dapsone prescription efficiently improved the adherence to safe prescription and monitoring guidelines
Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death
Dizziness
Given the history of dapsone therapy and the discordant result of self-monitoring blood glucose and HbA1c concentrations, we suspected methemoglobinemia as a cause
Consider referral
Some cases of CSU have a neutrophil-rich infiltrate on biopsy, although whether this histopathologic finding predicts response to dapsone in patients with CSU is unproven
Long-term administration of dapsone at standard doses (100 mg/day) results in methemoglobinemia in about 15% of patients
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by an extensive skin rash in association with visceral organ involvement, lymphadenopathy, eosinophilia, and atypical lymphocytosis
A potential severe dapsone intoxication requires close clinical and laboratory monitoring
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Dapsone (4,4'-diaminodiphenylsulfone) is Minocycline, 100 mg daily, can be used as a substitute for Dapsone in individuals who do not tolerate this drug