PMID: Results: At baseline, prior to initiation of amiodarone, the warfarin dose was 5
In turn, thyroid disorders may affect warfarin sensitivity, with hypothyroidism and thyrotoxicosis resulting in Data indicate that the interaction between warfarin and amiodarone results in an increased warfarin effect
Changes in the color or temperature of the skin
These results suggest that renal function is a novel factor that explains substantial variability in the warfarin-amiodarone DDI
An observational study of patients on a stable dose of warfarin demonstrated that the subsequent reduction in warfarin is proportional to the dose of amiodarone that is initiated
• Eight patients concurrently treated with amiodarone and warfarin sodium were studied to characterize the interaction between these drugs
The magnitude of the interaction between these two agents peaked at 7 weeks, which resulted in a 44% mean maximum reduction in the warfarin dose
Danshen can interact strongly with some heart medicines, such as: Blood thinners
2006; 40:753–757
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Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
Combining these medications can increase the risk of an irregular heart rhythm that may be serious
37 Though the results are yet to be published, edoxaban was found to be Interactions between ritonavir-boosted nirmatrelvir and chemotherapeutic agents should also be managed in consultation with the patient’s specialist providers