The summary results involving 98,445 lung cancer patients suggested that statin use was associated with the benefit of all-cause mortality, cancer-specific mortality, and Abstract Background: We investigated whether statin users had reduced risk of cancer-specific mortality in a population-based cohort of lung cancer patients
found that statins act as DNA methyltransferase (DNMT) inhibitors, demethylating the bone morphogenetic protein 2 (BMP2) promoter, activating BMP signaling, inducing differentiation of colorectal cancer (CRC) cells, and reducing "stemness" [ 5 ]
Lung (NSCLC) Simvastatin (40 mg/day) Meanwhile, this meta-analysis indicated that statin use did not affect the progression-free survival of lung cancer patients in observational studies and randomized controlled trials
Cardiovascular disease and lung cancer are two of the most common causes of death in the United States
Simvastatin also resulted in a decrease in the expression of phosphorylated Akt
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Lung cancer patient and advocate Jill Feldman takes pills at home that Lung cancer Lung cancer is the leading cause of cancer death among both men and women, accounting for about one-fifth of all cancer deaths
Both clinical and experimental studies on cancer cells suggest that some drugs (e
RB1 function may be also compromised by an increased expression of cyclin D1
However, the mechanism of simvastatin on lung cancer is still unclear
Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of cardiovascular disease but may also play an important role in the prevention and treatment of lung cancer
These included cancer characteristics, staging work-up and chemotherapy use
Statins dose-dependently reduced lung cancer risk in all subgroups and the main model with additional covariates (nonstatin drug use)
Simvastatin profoundly impaired Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of cardiovascular disease but may also play an important role in the prevention and treatment of lung cancer
Methods: In this phase 2 study, 61 patients received treatment with irinotecan (65 mg/m(2) ) and cisplatin (30 mg/m(2) ) on Days 1 and 8 every 3 weeks until either death or The impact of the 3-hydroxy-3methylglutaryl CoA reductase inhibitor simvastatin on human small-cell lung cancer (SCLC) cell growth and survival was investigated
Statin exposure both pre- and post-diagnosis was analyzed to identify a possible association with cancer-specific mortality in patients stratified by histological subtype
now show that fluvastatin inhibits lung cancer bone metastasis by triggering Statin treatments reduced the 5-year mortality (odds ratio, 0
Currently, statins are in use for preventing or treating cancer patients with prostate , breast , lung , liver , and other cancers (210, 211)
Lung cancer is one of the most common cancers, still characterized by high mortality rates
have revealed the role of statins in lung cancer
The protective effect of statin against lung cancer increased with statin duration
Rosuvastatin Calcium
Chemonaive patients with ED-SCLC, smoking history (≥100 cigarettes lifetime), and Eastern The feasibility and efficacy of statins in the prevention and treatment of lung cancer are discussed
2 million new cancer cases and 1
2 The risk of lung cancer is mainly associated with tobacco consumption 3; however, other Introduction
doi: 10 effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs
Metabolic reprogramming in tumors is an adaptation that generates vulnerabilities that can be exploited for developing new therapies
Materials and methods: Eligible papers of this meta-analysis were searched by using PubMed, EMBASE, and Cochrane until July 2017
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Abstract
Methods: Background Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer
For example, Kodach et al
In observational studies, the pooled HR indicated that statins potentially
Oncology; OBJECTIVE: To elucidate the molecular mechanism of Simvastatin on inhibiting malignant progression of lung cancer
In recent years, it has been documented that
250 specimens from lung cancer patients, 51 of whom were treated with statins (mainly Lung cancer is one of the most common cancers and has one of the lowest survival rates in the world
When a CT scan detects lung cancer early, patients have an 81% chance of living
The prospect of reducing the incidence and burden of some of the most prevalent cancers with a safe, affordable, and tolerable medication that already reduces
Lung cancer is the one of the most frequent causes of malignant tumors
It also found that
Simvastatin Can Enhance the Radiosensitivity of Colorectal Cancer Cells
Abstract
The safety, efficacy and mortality benefits of statins have been assessed both alone and in combination therapy in clinical cancer patients studies ( 212 – 214 )
Both clinical and experimental studies on cancer cells suggest that some drugs (e
There is an unmet clinical need to develop novel strategies to overcome resistance to tyrosine kinase inhibitors (TKIs) in patients with oncogene-driven lung adenocarcinoma (LUAD)
In addition, their levels in
In fact, they have suggested people taking statins are less likely to be diagnosed with prostate cancer and are living longer after a breast, colorectal, kidney or lung cancer diagnosis than people not on statins
23; 95% CI, 0
Methods: In this case-control study, we used information from the Taiwan National Health Institute Research Database on 17,329 patients (cases) aged 20 years or older recently diagnosed with lung cancer between 2005 and
Another case-control study observed an increased risk of
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First, they retrospectively analyzed patients diagnosed with lung cancer between 1998 and 2011, and found a high percentage of patients with p53 mutations observing a reduced 5-years mortality under simvastatin treatment in this population-based study (Chou et al