Cyclosporine, a calcineurin inhibitor
Successful Use of Cyclosporin A for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Three Children - St
There were also some promising
Abstract
The regimen was then tapered over 10 days using oral CsA and discontinued completely on day 21
Stevens-Johnson syndrome (SJS) is one such potentially lethal adverse drug reaction
The culprit and all other non-essential drugs were promptly discontinued
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are thought to represent variants of the same severe immunologic mucocutaneous reaction characterized by blister formation, hemorrhagic erosions, and epidermal necrosis
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, potentially life threatening, severe mucocutaneous adverse reactions characterized by extensive epidermal detachment, erosion of mucosae, and severe constitutional symptoms
SJS and toxic epidermal necrolysis (TEN) are considered to be the same condition on two ends of a spectrum, differing only by the extent of epidermal detachment
Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious conditions characterized by necrosis of the skin and mucus membranes, and are most frequently caused by medication, and less frequently by infections, mainly Mycoplasma pneumoniae
Erosions of two or more mucosal surfaces are commonly present, with oral mucosa Chatterjee M, Verma R
1 Texas A&M School of Medicine, Dallas
Rapid diagnosis of SJS/TEN is
Using the keywords [cyclosporine OR cyclosporine OR ciclosporin OR CsA] AND [Steven-Johnson OR SJS OR toxic epidermal OR epidermal necrolysis OR TEN OR hypersensitivity OR dermatologic OR burns], a preliminary search on the PubMed, Ovid, Web of Science, and Google Scholar Database yielded 615 papers
Over the last 5 to 10 years, a number of important Introduction
of acyclovir-induced Stevens-Johnson syndrome (SJS) was established