A Mestinon Miracle: Vagus Nerve Stimulating Drug Helps Long Time ME/CFS Patient Exercise A large (n=154) fibromyalgia trial that combined pyridostigmine bromide (PD)
Tompkins, MD, ScD Co-Director, The Harvard ME / CFS Collaboration Mestinon Trial Update In May, 2020, Open Medicine
Everything must be confirmed in larger studies
25 mg/kg/dose
Studies suggest that the PNS – which regulates the sympathetic nervous system (or fight/flight) system – is impaired in ME/CFS
Instead of enhancing HPA axis functioning, Mestinon
Most clinical trials involve one treatment but ME/CFS is a complex disease that is usually treated – when it’s treated successfully – in multiple ways
Mestinon (pyridostigmine) is a drug that prevents the breakdown of a chemical called acetylcholine that enables messages to be passed between nerves and muscles
This clinical trial will test the exercise
Pyridostigmine
In fact, three of the five drugs Systrom reported he uses in ME/CFS affect blood flows in one way or the other
I'm curious to hear your experiences (positive, negative, neutral) with the drug Mestinon (brand name)
A second iCPET was performed 50 min
Supplied in the Gulf War as 21-tablet blister pack, with prescribed dosage as one 30-mg tablet every 8 hours
Tracking in at somewhere around $350 million, the Congressionally Directed Medical Research Program (CDMRP) is not a small program
David Systrom in
Although generally well-tolerated, side effects from pyridostigmine are very common, are usually dose dependent, and can be debilitating necessitating reduction of dose or slower titration
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic neurologic disease often preceded by infection
placebo-controlled trial
See section ‘Pyridostigmine dose escalation protocol’