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Although adenosine has little effect on normal human airway smooth muscle in vitro, it constricts airways of patients with asthma via the release of histamine and leukotrienes, suggesting that If you have an overactive thyroid gland (hyperthyroidism)
If you are currently unwell with a high temperature (fever)
Tell your doctor if you smoke
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): Anxiety, nervousness
If you start or stop smoking tobacco or marijuana, talk with your doctor
Check with your doctor immediately if any of the following side effects occur while taking theophylline: Incidence not known Dose: 0
In the major guidelines for the treatment of COPD, theophylline is relegated to a third line bronchodilator after inhaled anticholinergics and β 2 agonists
In most individuals, a plasma-theophylline concentration of 10-20 mg/litre (55-110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma-theophylline concentration of 5-15 mg/litre may be effective
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of theophylline in the elderly
Adverse reactions to derivatives of theophylline were studied among 2,766 medical inpatients
Theophylline has been used for decades as a bronchodilator to treat asthma and chronic obstructive pulmonary disease (COPD)
However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving theophylline
administered theophylline intravenously 30 min prior to seizure induction to patients that developed seizure inhibition during a course of ECT
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
A change in your usual behavior or physical well-being may affect the way this medicine works Theophylline was first identified as having potential for asthma as a bronchodilator in 1921 and 1922 [ 1 ], but general use as a bronchodilator was not seen until the 1930s
Final follow-up ended on August 31, 2017
Theophylline in overdose can cause vomiting (which may be severe and intractable), agitation, restlessness, dilated pupils, sinus tachycardia, and hyperglycaemia
Call your child's doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away: Feeling nervous and excitable
Breastfeeding
Underactive thyroid—The effects of theophylline may be increased Proper Use
The bronchodilatory effects of theophylline are useful primarily for patients with asthma because bronchospasm is a key component of that disease state
Oral theophylline was commonly used in treatment of acute attacks of asthma and in chronic management of bronchospasm in patients with asthma and chronic obstructive pulmonary disease, but has been Therapeutic drug monitoring
Withdraw: 1
However, there is limited data on its effect on symptoms, exercise capacity or quality of life
Theophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting
However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day
0-25 s, P < 0
Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged headache, sleep loss, skin rash, or GI problems (nausea The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance
See Therapeutic Drug Monitoring
Patients who depended on mechanical ventilation were included in the study
Your doctor may want to take blood samples to determine whether a dose change is needed
If you drink alcohol, or smoke
Smoking: Smoking cigarettes or marijuana can affect the amount of theophylline in your body
If you have questions about side effects, call your doctor
Serious side effects of Theophylline Along with its needed effects, theophylline may cause some unwanted effects
Find patient medical information for theophylline oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings
Wether administered orally
At first, the dose is 12 to 14 milligrams (mg) per kg of body weight per day, divided and given every 4 to 6 hours
Final follow-up ended on August 31, 2017
You can also report side effects directly via HPRA Pharmacovigilance at www
COPD treatment: The treatment of acute COPD with theophylline IV is not supported or recommended by current clinical practice guidelines due to significant side effects (GOLD 2019)
In most cases, the side effects can be managed through dosage adjustments, and this will usually cause them to gradually
It is very important that your doctor check the progress of you or your child at regular visits, especially for the first few weeks after you begin using this medicine
Fifty‐eight patients (28%) received pentoxifylline (20%) or theophylline (8%), with 151 patients serving as the comparison group
Long-term theophylline use by patients with COPD results in improvement in other aspects of lung function, including vital capacity, FEV 1, minute ventilation, and gas exchange
0–25 s, P < 0
Over 20mcg is toxic
A total of 154 patients were divided in two group
4 mg/L two years ago before this current admission
Although adenosine has little effect on normal human airway smooth muscle in vitro, it constricts airways of patients with asthma via the release of histamine
Avoid drinks or foods that contain caffeine, such
Recently, theophylline was found to have several immunomodulatory and anti
After 3 days, if starting dose was tolerated: 16 mg/kg/day (max 400 mg) given as evenly divided doses every 4 to 6 hours