However, severe and late acute liver injury was not reported previously as an adverse reaction of CAP
Safety of capecitabine use in patients with liver dysfunction
Capecitabine, a prodrug of 5-Fluororuracil (5-FU) is activated through three enzymatic reactions
Abstract
A liver biopsy was then performed, and the pathological report was consistent with acute drug-induced liver injury (DILI) – toxic hepatitis
MS and NMS patients were matched for: presence of cirrhosis, etiology of liver disease, Child-Pugh score, ECOG-performance status, number of liver lesions
It undergoes hydrolysis in the liver and tissues to become fluorouracil
These events occurred in patients with and without liver metastases
Very rarely, this can cause heart failure or a heart attack
Fluorouracil (5-FU) is a pyrimidine analogue used as an antineoplastic agent to treat multiple solid tumors including colon, rectal, breast, gastric, pancreatic, ovarian, bladder and liver cancer
Those with active central nervous system disease, prior capecitabine, a history of autoimmune disease, active pneumonitis or prior severe pneumonitis requiring steroids or gastrointestinal disease that may impair capecitabine absorption were excluded
The most common chemotherapy drugs for treating liver cancer include: Gemcitabine (Gemzar) Oxaliplatin (Eloxatin) Cisplatin
6
weight gain or loss
Dehydration can happen with XELODA and may affect how well your kidneys work
Food reduced both the rate and extent of absorption of capecitabine with mean C max and AUC 0-∞ decreased by 60% and 35%, respectively
Toxicity from Capecitabine typically involves hand-foot syndrome, fatigue, nausea, reduced appetite, and diarrhea, while severe liver toxicity is rarely seen
Pathology Etiology
Neuroendocrine liver metastases (NELM) are heterogeneous in clinical presentation and prognosis
For patients with partial DPD deficiency, a Metronomic capecitabine was well tolerated in hepatocellular carcinoma patients who had been treated with sorafenib