Malonic ester synthesis valproic acid

Malonic esters are more acidic than simple esters, so that alkylations can be carried out via enolate formation promoted by relatively mild bases such as sodium alkoxide, and subsequent alkylation with halides. Apart from this, VPA has potential therapeutic applications in other central nervous system (CNS) disorders and in various cancer types

2024-03-29
    Hydrochlorothiazide u 123
  1. Step 1: Sodium carbonate produces sodium salt
  2. decarboxylation of the carboxylic acid to give an enol 5