The cfr gene is often located on transferable plasmid and is thus considered to promote horizontal spread of linezolid resistance
Notably, tedizolid-resistant isolates appear to be independent of the mobile LNZ resistance gene cfr, and isolates harbouring the cfr gene are susceptible to tedizolid [52]
Six resistant isolates were identified, three each in MRSA and S
The cfr gene was flanked by two copies of the IS256-like element, with a downstream orf1 gene
PFGE analysis displayed close genetic relatedness between these linezolid-resistant isolates
L3 mutations coupled with the cfr and fexA genes may act synergistically
Linezolid resistance cfr gene was detected only in 9
pDM86-3-optrA encoded the RDK-type OptrA protein and a common genetic array of 'IS1216
These conformational changes are the result of mutations in genes encoding 23S rRNA (2, 3) or the ribosomal proteins L3 and L4 (4, 5) or via posttranscriptional modification of
50 821–825
The mechanisms of linezolid resistance among 86 staphylococcal isolates from two intensive care units were investigated
aureus and S
Rates of S
aureus and coagulase-negative staphylococci), followed by the presence of the cfr gene (54% of S