Imipramine has an average rating of 7
Reference Oefele, Grohmann and
1981 Sep;1(5):316-9
The single dose kinetics of imipramine (IP), nortriptyline (NT), and antipyrine (AP) were compared in 7 healthy subjects
Most of the investigators to date have been comparing desipramine with imipramine, and little work has been published on comparative studies of the
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51 to -0
The authors reported cross-sectional and longitudinal analyses comparing TCAs (Imipramine, Amitriptyline, Nortriptyline, Desipramine, Amoxapine, Clomipramine, Doxepin, Maprotiline, etc
The reference cited for this statement by Comparison of automated REM and slow-wave sleep analysis in young and middle-aged depressed subjects
Psychiatry 17, 535–546 [Google Scholar] The combination of a predominantly noradrenergic TCA such as nortriptyline and an SSRI may overcome this ceiling effect and produce a different sodium:5-HT reuptake blockade ratio
8% and 12
Neither response nor remission rates statistically differed by treatment, nor did these two treatments differ in tolerability or adverse events
Johnson and Jan Vita and J
The elimination half-life of imipramine is longer and its plasma clearance is markedly reduced in elderly subjects when compared to values reported in young adults, and caution should be exercised before initiating and during the treatment of elderly patients with these antidepressant drugs
DOI: 10
Animal studies suggest that the toxicity of both imipramine and MAO inhibitors may be increased in
In the case of nortriptyline, a brand-name, non-generic form exists, known as Pamelor
0
Fibromyalgia is a complex chronic condition characterized by widespread pain, physical fatigue, non-restorative sleep and cognitive impairment [1,2]
In terms of efficacy, fluoxetine plus cognitive behavioural therapy (CBT) was more effective than CBT alone (–0·78, 95% CrI −1·55 to −0·01) and psychodynamic therapy (–1·14, −2·20 to −0·08), but not more effective than